Abemaciclib-associated acute interstitial nephritis successfully treated with glucocorticoids: a case report and literature review.

ABSTRACT:

Background

Drug-induced acute interstitial nephritis (DI-AIN) is the most common type of AIN. DI-AIN occurs when medications trigger a T cell-mediated immune response that promotes tubulitis and interstitial inflammation with eosinophils, often resulting in acute kidney injury (AKI) with nephromegaly. Recently, prolonged use of cyclin-dependent kinase (CDK) 4/6 inhibitors, as oral molecular-targeted drugs for breast cancer, was identified as a cause of AKI, including AIN and acute tubular necrosis (ATN). To date, there have been no reported cases of AIN associated with the use of abemaciclib, a CDK4/6 inhibitor.

Case presentation

A 66-year-old Japanese woman presented with persistent diarrhea and nausea shortly after the initiation of abemaciclib for breast cancer and was su

SUBMITTER: Kumano M 

PROVIDER: S-EPMC12482685 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature