Assessment of frailty in patients with advanced chronic kidney disease, and the role of microvesicles: A single-center study.

ABSTRACT:

Background

Frailty is a highly prevalent syndrome in patients with advanced age and chronic diseases, and it is associated with atherothrombotic pathologies, suggesting a procoagulant state in these patients. Circulating microvesicles (cMVs), are small phospholipid-rich vesicles, which have been shown to participate in atherothrombotic onset and progression. We aim to analyze frailty in patients with advanced chronic kidney disease (CKD), and to determine the role of microvesicles in this population.

Materials and methods

We conducted a prospective cohort study with 85 patients with advanced CKD. Our main objective was to evaluate frailty and its novel association with circulating microvesicles in advanced CKD. To define frailty, Fried's five criteria were used and we obtain

SUBMITTER: Gimena Munoz R 

PROVIDER: S-EPMC12483209 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature