The impact of transcranial direct current stimulation on brain network connectivity and topology in post-stroke cognitive impairment patients: a resting-state fMRI study.

ABSTRACT:

Background

Post-stroke cognitive impairment (PSCI) is a common and severe consequence of ischemic stroke (IS) that significantly affects patient outcomes. Transcranial direct current stimulation (tDCS) has shown promise in enhancing cognitive function in IS patients, but its underlying mechanisms are not fully understood. This study investigates the effects of tDCS on brain functional connectivity and network topology using resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

In this double-blind study, sixty-five IS patients with PSCI were randomly assigned to either the tDCS or control group. Rs-fMRI data were acquired before and after the intervention. We analyzed functional connectivity (FC) and graph theory-based topological properties. Cognitive perfo

SUBMITTER: Zhong J 

PROVIDER: S-EPMC12488762 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature