Cellular phospho-signaling map of the enigmatic serine/threonine kinase MAST2.

ABSTRACT:

Background

MAST2 (Microtubule-Associated Serine/Threonine Kinase 2) is an enigmatic serine/threonine kinase that is considered to bridge microtubule-associated cytoskeletal architecture through its phospho-regulatory networks. Yet, MAST2 remains a dark horse in the human kinome, as the molecular details on its structure, upstream regulators, and downstream phosphorylation targets remain unknown.

Methods and results

To interpret MAST2-linked phospho-signaling dynamics, PubMed-indexed articles were curated based on predefined MeSH terms to obtain global cellular phosphoproteomics datasets. Among 105 class I phosphosites in MAST2 identified across cellular phosphoproteomics datasets, 2 phosphosites, S74 and S148, were represented more abundantly compared to other phosphosites,

SUBMITTER: Fathima I 

PROVIDER: S-EPMC12489769 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature