Self-Assembly Properties of Xylene-Derived Constitutional Isomers of Fmoc-Phenylalanine.

ABSTRACT: Fluorenylmethoxycarbonyl-phenylalanine (Fmoc-Phe) derivatives are a privileged molecular class that readily undergoes supramolecular self-assembly into hydrogel networks. Herein, we characterize the self-assembly properties of xylene-derived constitutional isomers of Fmoc-Phe, demonstrating the impact of molecular configuration on the emergent structure and properties of supramolecular assemblies of these derivatives. The self-assembly properties of Fmoc-Phe and a cationic derivative of Fmoc-Phe that has been modified at the C terminus with diaminopropane (DAP), Fmoc-Phe-DAP, were compared to those of several corresponding xylene derivatives in which Fmoc-functionalized amine and carboxylic acid or DAP-functionalized carboxylic acid are organized around a central benzene ring, with the app

SUBMITTER: Agredo P 

PROVIDER: S-EPMC12490004 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature