Development and validation of a nomogram for predicting high-risk pathology in clinical stage lA left upper lobe lung adenocarcinoma.

ABSTRACT:

Background

Accurate preoperative identification of high-risk pathological features in early-stage lung adenocarcinoma is critical for guiding surgical decisions and improving patient outcomes. This study aimed to develop and validate a nomogram to predict high-risk pathology in clinical stage IA lung adenocarcinoma located in the left upper lobe (LUL), an anatomical site with distinct surgical implications.

Methods

We retrospectively reviewed 545 patients with clinical stage IA LUL adenocarcinoma who underwent surgery between January 2018 and May 2022. The cohort was randomly divided into training (80%) and validation (20%) sets. Independent predictors were identified via multivariate logistic regression and further validated using LASSO regression. A nomogram was constructe

SUBMITTER: Luo D 

PROVIDER: S-EPMC12495665 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature