Production and radiochemistry of the in vivo PET generator ¹⁴⁰Nd/¹⁴⁰Pr as an imaging surrogate for F-block therapeutic radionuclides.

ABSTRACT: Theranostics, a combined approach of diagnostics and therapeutics, often employs F-block therapeutic radionuclides including ²²⁵Ac, ¹⁷⁷Lu, and ¹⁶¹Tb. While there is a lack of F-block PET imaging radionuclides, the in vivo PET generator pair ¹⁴⁰Nd/¹⁴⁰Pr can act as a theranostic imaging counterpart to the F-block therapeutic radionuclides. In this study, we explored the production and separation of high purity ¹⁴⁰Nd via the ¹⁴¹Pr(p,2n)¹⁴⁰Nd reaction route. Monoisotopic ¹⁴¹Pr targets irradiated with 20 MeV protons for 10 min with 10 µA beam current yielded 21.45 ± 0.82 MBq (580 ± 22 µCi) of ¹⁴⁰Nd. A two-step separation method was developed for the purification of ¹⁴⁰Nd from

SUBMITTER: Godara ML 

PROVIDER: S-EPMC12504599 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature