Epigenetic Clocks as Biomarkers for Bone Aging: Evidence From a Twin Study.

ABSTRACT: Osteoporosis is driven by skeletal aging and increases the risk of fragility fractures. Skeletal aging is influenced by epigenetic mechanisms; however, the link to the epigenetic clocks, that is, the suggested biomarkers of biological aging intensively studied within aging research, remains largely unexplored. We investigated the association of eight epigenetic clocks-Horvath, IEAA, Hannum, EEAA, PhenoAge, GrimAge, DunedinPoAm, DunedinPACE-and methylation-based telomere length (mTL) measured at intake (1997, 2007, or 2008-11) with register-based incident fracture and osteoporosis diagnoses in 310 (Discovery cohort), and 777 (Replication cohort) twins, derived from nationwide population-based surveys (end-of-follow-up: 2022). For the 288 youngest twins, bone mineral density (BMD), and bone

SUBMITTER: Soerensen M 

PROVIDER: S-EPMC12507416 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature