Clinical nodal staging to assess the risk of local recurrence after rectal cancer resection: A nationwide cross-sectional study.

ABSTRACT:

Aim

In rectal cancer, neo-adjuvant (chemo)radiotherapy (n(C)RT) should be used selectively, due to related toxicity. The decision to offer n(C)RT is mainly based on preoperative MRI staging. cN category has limited accuracy and its use when deciding on n(C)RT is controversial. This population-based study aimed to assess the association between cN category and local recurrence (LR) rate.

Method

Data from a national cross-sectional cohort of patients who underwent curative resection of primary rectal cancer in the Netherlands in 2016 were used. Patients were subdivided by neo-adjuvant treatment strategy: no n(C)RT, short-course RT with short interval to surgery (SCRT-SI) or downstaging therapy (SCRT with long interval to surgery, CRT, total neoadjuvant therapy or chemotherapy

SUBMITTER: Ubink M 

PROVIDER: S-EPMC12508276 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature