Functional characterization of LSM12 as a driver in uveal melanoma oncogenesis.

ABSTRACT:

Objective

This study aimed to investigate the role of LSM12 in uveal melanoma (UM) oncogenesis and progression, examining its potential as both a prognostic biomarker and therapeutic target.

Methods

LSM12 expression was analyzed in relation to RNA modification genes and tumor stemness in UM. UM cell lines were subjected to LSM12 knockdown using siRNA, followed by cell viability and migration assays. The therapeutic potential of targeting LSM12 was evaluated using a subcutaneous xenograft model. Additionally, the relationship between LSM12 and the PI3K/Akt/mTOR pathway was explored.

Results

LSM12 expression levels were significantly elevated in UM patients, correlating strongly with poor prognosis. Positive correlations were observed between LSM12 expression and multip

SUBMITTER: Tang J 

PROVIDER: S-EPMC12509769 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature