Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS.

ABSTRACT:

Objective

This study aims to investigate alterations in glymphatic system (GS) function in patients with non-alcoholic fatty liver disease (NAFLD) and explore the relationship of these alterations with cognition and clinical indicators.

Materials and methods

In this cross-sectional study, forty-three patients with pre-cirrhotic NAFLD (male: 37, mean age: 38.2 ± 6.7 years) and twenty-three age-, sex-, and education-matched controls (male: 17, mean age: 41.0 ± 6.7 years) underwent diffusion tensor imaging (DTI) examination and cognitive measurements. The DTI analysis along the perivascular space (DTI-ALPS) index, calculated from the DTI data, assessed differences in GS function between the two groups. Linear regression analysis examined the relationship between the ALPS index

SUBMITTER: Shu K 

PROVIDER: S-EPMC12512909 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature