Empirical Rescue Eradication Therapy for Helicobacter pylori Infection in Second and Subsequent Treatment Lines: Experience From 500 Cases of the Brazilian Registry on H. pylori Management (Hp-BrazilReg).

ABSTRACT:

Background

The effectiveness of anti-H. pylori treatment diminishes with therapy failure, making regional performance understanding crucial.

Objective

To evaluate the effectiveness of empirical therapy in second-line and subsequent treatments in Brazil.

Methods

A multicenter, prospective, noninterventional registry assessed H. pylori management outcomes by Brazilian gastroenterologists (Hp-BrazilRe, Hp-WorldReg's partner). Data were registered at e-CRF AEG-ReCap from March 2022 to October 2024 and analyzed via modified intention-to-treat (mITT) methodology. Data were subject to quality review.

Results

572 patients (mean age 52 years, 64% women) were included. The primary treatment indications were dyspepsia (64%) and gastroduodenal ulcer (9.2%). Among them, 67%

SUBMITTER: Sanches BSF 

PROVIDER: S-EPMC12521799 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature