Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App: A Randomized Clinical Trial.

ABSTRACT:

Importance

Excess salt intake is a major modifiable risk factor for hypertension and cardiovascular disease. Personalized interventions using genetic information and digital tools, such as smartphone applications, may enhance sodium reduction, but evidence remains limited.

Objective

To evaluate the effectiveness of a sodium reduction program incorporating a genetic profile and an artificial intelligence (AI)-based mobile app among adults with elevated blood pressure and a sodium-sensitive genotype.

Design, setting, and participants

A 3-arm randomized clinical trial, conducted at a Japanese electronics company from September 17 to December 16, 2024, included employees aged 20 to 65 years with elevated blood pressure and the sodium-sensitive AGT M235T genotype.

Inter

SUBMITTER: Sato K 

PROVIDER: S-EPMC12531883 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature