Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer.

ABSTRACT: Diagnosis of stage 1 breast cancer is challenging as small tumors are often left undetected by conventional imaging techniques. In addition, ~80% of detected breast masses are classified as benign, which means that a large proportion of diagnostic needle biopsies lead to unnecessary psychological stress and medical costs. We investigated circulating extracellular vesicles (EVs) as potential carriers of unique cancer-associated proteins capable of reporting on a breast cancer diagnosis. We isolated EVs from healthy (19), benign (19), and stage 1 breast cancer patient (86) plasma samples using size exclusion chromatography. Mass spectrometry identified 94 significantly changed proteins in the plasma EVs from breast cancer patients. Analysis of a subset of these proteins using a cohort of pre

SUBMITTER: Salmond N 

PROVIDER: S-EPMC12534435 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature