Cappable-Seq reveals the transcriptional landscape of stress responses in the bacterial endosymbiont <i>Wolbachia</i>.

ABSTRACT: Bacterial endosymbionts are highly prevalent among invertebrate animals, in which they can confer fitness benefits such as pathogen defence and/or act as reproductive manipulators, inducing phenotypes including cytoplasmic incompatibility (CI). For the alpha-proteobacterium Wolbachia, its wide distribution among macroparasites and disease-transmitting arthropods coupled with mutualistic roles, reduction of vector competence and CI has found recent applications in the control of several vector-borne tropical diseases. However, in common with other bacterial endosymbionts, which often lose regulatory elements during genomic erosion, the degree to which Wolbachia can respond to environmental or pharmacological stressors is poorly understood. Here, we apply Cappable-Seq methodolo

SUBMITTER: Suliman Y 

PROVIDER: S-EPMC12558409 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature