STOP Strategy to Inhibit <i>P. falciparum</i> and <i>S. aureus</i> Growth: Molecular Mechanism Studies on Purposely Designed Hybrids.

ABSTRACT: Background/Objectives: Malaria remains the most critical parasitic disease globally, responsible for over 600.000 deaths annually. In sub-Saharan Africa, co-infections of Plasmodium falciparum with other pathogens, particularly Staphylococcus aureus, are common in children with severe malaria. Therefore, the design of new compounds targeting both pathogens appears to be an urgent priority. Methods: A small series of hybrid compounds was designed and synthesized by linking the pharmacophore of the antimalarial drug chloroquine with the phenothiazine core. These compounds were tested in vitro against a panel of microbial strains and further analyzed through in silico simulations to predict their physical-chemical properties. Results: Compounds 4b and

SUBMITTER: Gianibbi B 

PROVIDER: S-EPMC12561106 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature