Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.

ABSTRACT: The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major metabolism-related peripheral organs or immune system dysfunction. Multi-organ metabolomic profiling and network analysis of aged mice (24 months old) identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis. Dynamic gut microbiota profiling via series expression miner-based longitudinal analysis reveals that nicotine consumption preserved microbiota composition and altered microbial-derived metabolites associated with the sphingolipid pathway, known to regulate age-related mu

SUBMITTER: Jia S 

PROVIDER: S-EPMC12561400 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature