Pequi (<i>Caryocar brasiliense</i>, Camb) Bark Extract Reduces ROS Production in Diabetic Human Coronary Endothelial Cells.

ABSTRACT: Reactive oxygen species (ROS) overproduction contributes to endothelial dysfunction in Type 2 diabetes mellitus (T2DM). Pequi (Caryocar brasiliense, Camb), a native Brazilian fruit, is rich in polyphenolic antioxidants. We investigated whether its ethanolic bark extract modulates ROS levels and promotes proliferation in human coronary artery endothelial cells from patients with diabetes (D-HCAECs). Cells were treated with pequi extract under normoxic, hypoxic, or H₂O₂-induced oxidative stress conditions. Cytosolic and mitochondrial ROS levels, cell proliferation, and the expression of antioxidant proteins (Nrf2, HO-1, SOD1, SOD2, catalase, and GPx1) were assessed. Pequi significantly reduced cytosolic ROS under normoxia and both cytosolic and mitochondrial ROS

SUBMITTER: Braga KMS 

PROVIDER: S-EPMC12562227 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature