Ulvan-Na, an Ulvan Subjected to Na⁺ Cation Exchange, Improves Intestinal Barrier Function in Age-Related Leaky Gut.

ABSTRACT: The global increase in life expectancy underscores the need to promote healthy aging, particularly by addressing age-related leaky gut syndrome, which contributes to systemic inflammation and chronic disease. This study focused on the sustainable production and functional development of Ulva meridionalis, a fast-growing seaweed, to improve gut health and mitigate the effects of aging. Using land-based aquaculture, a scalable cultivation system for U. meridionalis was established, and its polysaccharide, ulvan, was extracted. Ion exchange treatment enhanced the functionality of ulvan to produce ulvan-Na, which contains high levels of Na⁺ and conveys superior anti-aging properties. Ulvan-Na restored intestinal barrier integrity in aged mice by reducing serum LPS leve

SUBMITTER: Maejima Y 

PROVIDER: S-EPMC12565729 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature