The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts.

ABSTRACT:

Introduction

It remains unclear whether diabetes mellitus (DM) is associated with Alzheimer's disease (AD) pathology and associated vascular burden.

Methods

We included cognitively normal (CN), mild cognitive impairment (MCI), and dementia individuals. We assessed associations between DM and AD biomarkers (amyloid beta [Aβ], phosphorylated tau-181 [p-tau181], total tau [t-tau], and medial temporal atrophy [MTA]) and vascular burden (white matter hyperintensities, microbleeds) by logistic regression. Secondary analyses assessed associations between DM and profiles of Aβ combined with p-tau181/t-tau/MTA/white matter hyperintensity/microbleeds.

Results

We included 5550 participants (65.8+-8.7 years, 8.7% DM). DM was associated with lower odds of abnormal AD biomarkers: A

SUBMITTER: van Gils V 

PROVIDER: S-EPMC12573102 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature