Clinical evaluation of a novel Mologic malaria Plasmodium falciparum LDH-dependent lateral flow rapid diagnostic test diagnostic accuracy: a cross-sectional study, Sudan.

ABSTRACT:

Background

Malaria diagnosis by Rapid Diagnostic Test (RDT) is challenged by the newly emerging histidine-rich protein 2 (HRP2) gene deletion in the Plasmodium falciparum species. The alternative lactate dehydrogenase (LDH)-dependent RDTs suffer from low sensitivity, and improvement in the sensitivity of LDH RDTs is the cornerstone for detecting the (HRP2) gene deletion species. This study aimed to evaluate a novel, improved Mologic Malaria Pf LDH-dependent RDT for the diagnosis of P. falciparum malaria in partnership with the Foundation for Innovative Diagnostics (FIND), Switzerland.

Methods

This is a descriptive cross-sectional study evaluating the clinical performance of the improved Mologic LDH- RDT in two rural sites in Khartoum state, Sudan. Five hundred patients prese

SUBMITTER: Mohamed AO 

PROVIDER: S-EPMC12574065 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature