Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis.

ABSTRACT: Diabetes mellitus (DM) exacerbates periodontitis as the high-glucose (HG) environment aggravates local inflammation and periodontal bone resorption. Restoring periodontal homeostasis and promoting periodontal bone repair/regeneration are major challenges for the treatment of diabetic periodontitis. This study introduces antler stem cell-derived exosomes (AnSC-exos) as a potent therapeutic for treating diabetic periodontitis via leveraging the shared cranial neural crest cell (CNCC) origin of antlers and periodontal tissues. Using a rat model of diabetic periodontitis, we demonstrate that AnSC-exos effectively alleviate tissue abnormalities and alveolar bone destruction and resorption in periodontitis under DM conditions; the outcome was significantly more potent than human bone marrow mese

SUBMITTER: Guo Q 

PROVIDER: S-EPMC12583464 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature