Burden of Central Nervous System Cancer in the United States, 1990-2021.

ABSTRACT:

Importance

Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States.

Objective

To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and Sociodemographic Index (SDI).

Design, setting, and participants

This cross-sectional study involved a repeated analysis of Global Burden of Disease Study (GBD) 2021 data in 2024. Using data from 183 sources, CNS cancer metrics in the US were estimated across states and years. US CNS cancer metrics across all sexes and age groups were included in the GBD.

Exposure

CNS cancer diagnosis.

Main outcomes and measures

Overall and age-sta

SUBMITTER: GBD 2021 US CNS Cancer Collaborators 

PROVIDER: S-EPMC12584065 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature