Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.

ABSTRACT:

Background and aims

Recent large studies have established the genetic basis of several conceptually linked phenotypes of externalizing. Polygenic risk scores (PRSs) for these constructs are associated with a range of substance use and mental disorder phenotypes but have not been examined with both pharmacological and non-pharmacological addictive behaviors, or across a developmental window. This study identified biological pathways responsible for observed associations between PRSs and addiction phenotypes.

Design, setting, participants

We selected genome-wide association studies of 22 phenotypes, including substance use, general factors of externalizing and addiction, impulsivity and psychiatric conditions. Using summary statistics, we constructed PRSs in the offspring from

SUBMITTER: Deng WQ 

PROVIDER: S-EPMC12586799 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature