Metal fluoride nanoregulators reverse therapeutic resistance via stemness remodeling to trigger pyroptosis for chemoimmunotherapy.

ABSTRACT: Chemoresistance and immunosuppression serve as major obstacles that compromise the therapeutic efficacy of chemoimmunotherapy. Herein, we reported a novel chemoimmunotherapy strategy employing metal fluoride to modulate Wnt/β-catenin signaling, effectively remodeling treatment resistance and eliciting pyroptosis-mediated immune activation. Through systematic screening of various nonmetallic anions (F^-, Cl^-, Br^-, I^-, CO₃ ^2-, PO₄ ^3-, S^2-, and Se^2-), we identified F^- as an effective inhibitor of β-catenin expression and tumor stemness. The synergistic combination of F^- with chemotherapy significantly attenuated tumor stemness and enhanced treatment efficacy. We f

SUBMITTER: Sun S 

PROVIDER: S-EPMC12590230 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature