Interactive effects of Bisphenol F exposure and TLR4 rs4986790 on unexplained miscarriage.

ABSTRACT:

Background

Unexplained miscarriage (UM) occurs frequently and significantly limits global human reproduction. However, till now, whether environment-gene interactions might interactively regulate UM has not been well characterised.

Methods

We combined epidemiological study using a UM case-control group and in vitro functional assays using mouse model and human trophoblast HTR-8/SVneo cells. The interactions between environmental exposure to Bisphenol F (BPF) and genetic variation in TLR4 rs4986790 (A896G) were explored. Trophoblast cell migration and invasion (key functions for healthy pregnancy), the interactions between TLR4 variants and β2GPI (β-2 glycoprotein I, an inflammatory mediator), and the downstream signalling molecules MMP9 and RAC1 were investigated.

Finding

SUBMITTER: Wang M 

PROVIDER: S-EPMC12595282 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature