Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study.

ABSTRACT:

Background

Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the understanding of the mechanisms related to the benefits of physical activity.

Methods

Pooled observational (cases: n = 5386; controls: n = 6798; studies n = 5) and genome-wide association data (cases: n = 8178; controls: n = 10 472; studies n = 5) were used. We used multivariable logistic regression models and Mendelian randomization to assess the association between physical activity and the risk of CRC subtypes defined by individual tumor markers (and marker combinations), namely microsatellite instability status, CpG island methylator phenoty

SUBMITTER: Chalitsios CV 

PROVIDER: S-EPMC12596107 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature