Sputum Cellularity and MRI Ventilation Defects in Severe Asthma.

ABSTRACT:

Background

Airway inflammation is a hallmark feature of asthma characterized by elevated eosinophils and/or neutrophils. Eosinophils in sputum can contribute to ventilation defects. The functional consequence of other types of cellularity on ventilation is unknown.

Research question

What is the effect of different sputum cellular phenotypes on abnormal ventilation evaluated by ¹²⁹Xe MRI in patients with severe asthma?

Study design and methods

Eighty-five patients with severe asthma and 15 healthy control participants underwent ¹²⁹Xe ventilation MRI. Sputum cytometry was performed to evaluate airway inflammation and to stratify patients with asthma into 4 cellular phenotypes (paucigranulocytic, eosinophilic, neutrophilic, and mixed-granulocytic).

SUBMITTER: Serajeddini H 

PROVIDER: S-EPMC12597553 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature