Exploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum.

ABSTRACT:

Purpose

Observational data suggest that women conceiving without a corpus luteum are at higher risk of developing preeclampsia. While the underlying mechanisms remain unclear, the absence of corpus luteum-derived secretory products may be a contributing factor. This study investigates whether the plasma proteome differs between women who conceive with or without a corpus luteum and examines the relationship with mode of conception.

Methods

Plasma samples from 12 participants were collected at three time points: first trimester, third trimester, and postpartum. The cohort included women who conceived unassisted (UC) after infertility, via artificial cycle frozen embryo transfer (AC FET), or natural cycle frozen embryo transfer (NC FET). A total of 36 plasma protein samples we

SUBMITTER: Ramachandran D 

PROVIDER: S-EPMC12602745 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature