Characterization of the Fecal Metabolome in Patients With Early Systemic Sclerosis.

ABSTRACT:

Objective

To evaluate the fecal metabolome in patients with early systemic sclerosis (SSc) compared with unaffected controls and to determine if altered metabolites are associated with specific bacterial genera in patients with early SSc.

Methods

Stool samples and clinical data were collected from 106 patients with early SSc and 79 unaffected control patients. Targeted metabolomics was performed on fecal samples using liquid chromatography mass spectrometry, and 16S ribosomal RNA gene sequencing was used to determine the microbial composition of fecal samples.

Results

Compared with unaffected controls, patients with early SSc had higher levels of nicotinamide, 5'-methylthioadenosine, and several short-chain fatty acids (SCFAs) including valeric acid, propionic acid, a

SUBMITTER: Young AC 

PROVIDER: S-EPMC12606447 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature