Distinct hydrogen atom transfer and radical capture reactivity of copper(iii) OH/F complexes enables site-selective C(sp³)-H ¹⁸F-fluorination.

ABSTRACT: High-valent metal intermediates play a key role in C(sp³)-H functionalization reactions in both enzymatic catalysis and organometallic chemistry. Despite its generality, this strategy often requires a single metal complex to efficiently mediate both hydrogen atom transfer and radical capture-a combination challenging to achieve. To overcome this limitation, we propose a decoupled approach, where separate high-valent metal complexes independently perform hydrogen atom transfer (HAT) and radical capture (RC). As a proof of concept, we leveraged the complementary reactivity of copper(iii) hydroxide (efficient for HAT) and copper(iii) fluoride (efficient for RC) to develop a decoupled ¹⁸F-fluorination protocol. The distinct reactivity of copper(iii) hydroxide and copper(i

SUBMITTER: Queener JA 

PROVIDER: S-EPMC12606465 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature