The diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus.

ABSTRACT: Vibrio vulnificus is a marine pathogen that is a significant cause of foodborne infections, leading to chronic diseases and primary septicemia. Wound infections caused by this bacterium can result in serious complications such as ulceration and tissue necrosis. The pathogenesis of V. vulnificus is influenced by quorum sensing and the secondary messenger cyclic diguanylate (c-di-GMP). The levels of c-di-GMP inside the cell are controlled by its synthesizer, diguanylate cyclase, and its degrader, phosphodiesterase. The phosphodiesterase VieA serves as a key transcriptional regulator in V. cholerae's virulence. However, the function of its diguanylate cyclase partner in locally controlling c-di-GMP-mediated virulence regulation in V. vulnificus remains unclear. This study identified a diguany

SUBMITTER: Yang JR 

PROVIDER: S-EPMC12619232 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature