Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice.

ABSTRACT: Anorexia nervosa (AN) is the most severe and life-threatening eating disorder. Its pathophysiology remains largely unknown, and no effective treatment currently exists for severe forms of the disease. Gut microbiota (GM) dysbiosis has been consistently reported in AN; however, no study has yet considered the role of the microbiota within the full spectrum of AN symptoms. To investigate the direct involvement of the microbiota in disease symptoms, we developed a murine model of fecal microbiota transplantation (FMT), using germ-free BALB/c mice colonized with fecal samples from well-characterized AN patients and healthy controls. Physiological, organ, and behavioral parameters were systematically monitored. We found that key AN-related features (including food restriction, anxiety-like beha

SUBMITTER: Gabriel-Segard T 

PROVIDER: S-EPMC12626428 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature