SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells.

ABSTRACT:

Introduction

Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation of lipid peroxides. Understanding the regulatory mechanisms of ferroptosis and developing strategies to target this process hold significant clinical applications in tumor therapy.

Objective

Our study aims to search for novel candidate genes involved in the regulation of ferroptosis and to investigate their mechanism of action in ferroptosis and tumor therapy.

Methods

We employed a CRISPR-Cas9 library to perform a genome-wide screen under ferroptosis inducer treatment conditions, revealing Scavenger Receptor Class B Member 1(SCARB1) as a novel candidate gene involved in ferroptosis regulation. Subsequently, lipidomic analyses, metabolic interventions, and relevant

SUBMITTER: Mao X 

PROVIDER: S-EPMC12627352 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature