The Synergistic Cytotoxic Effect of the Two Enantiomers of 6‑Prenylflavanones in the HeLa Cell Line.

ABSTRACT: This research performed a structure-activity relationship (SAR) study, which involved the synthesis of 16 (2R/S)-6-PFVNs and evaluating their cytotoxic effects on the HeLa cell line. This investigation concentrated on the length of the prenyl side chain at the C-6 position of the A-ring and the substitution patterns of the methoxy and hydroxy groups on the B-ring. Accordingly, several (2R/S)-6-PFVNs were identified as having strong cytotoxic effects on HeLa cells. Among them, (2R/S)-6-(3,3-diethylallyl)-naringenin (6-DEANG) emerged as a standout candidate, demonstrating an IC₅₀ value of 12 μM and a selectivity index (SI) exceeding 10. Furthermore, the synergistic effect of (2R)-6-DEANG and (2S)-6-DEANG on the treatment of HeLa cells with (2R

SUBMITTER: Nguyen D 

PROVIDER: S-EPMC12631367 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature