Androgens Drive SOX9 Upregulation in Injured Proximal Tubular Cells.

ABSTRACT:

Introduction

Sex influences susceptibility, recovery, and long-term outcomes after acute kidney injury (AKI) in humans. Rodent models have been invaluable for elucidating AKI mechanisms; however, most studies have focused on males, assuming direct applicability to females, an assumption that remains largely untested. In males, the transcription factor SOX9 regulates injury-associated proximal tubule cell states, supporting survival during injury but also contributing to maladaptive repair. Given the well-described role of SOX9 in sex determination during development and its emerging importance in AKI, we investigated whether it mediates sex-specific tubular responses in the adult kidney.

Methods

We first optimized differential ischemic and cisplatin conditions in males and f

SUBMITTER: Allison CV 

PROVIDER: S-EPMC12633231 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature