The Function of <i>Efhd1</i> ⁺ Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis.

ABSTRACT: Resting collecting lymphatic vessels (cLVs) sense edema in distal joints and initiate contractions via unknown mechanisms. Rheumatoid arthritis (RA) patients have lymphatic drainage deficiencies from affected joints, and defects in the synovial lymphatic system exacerbate inflammatory-erosive arthritis in animal models. To understand this, we generated Efhd1-CreER^T2 and Myoc-CreER^T2 mice for cell-specific genetic gain and loss of function studies. These mice were crossed with tdTomato reporter (Ai9) mice, and studies showed selective tamoxifen-induced transgene expression in CD31^-/CD34⁺ telocyte-like cells in knee and ankle synovium, and in networks physically associated with mast cells proximal to popliteal lymphatic vessels (PLVs)

SUBMITTER: Peng Y 

PROVIDER: S-EPMC12637515 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature