Neurophysiology of mismatch negativity generation: a biophysical modeling study.

ABSTRACT: The mismatch negativity, or MMN, is a ubiquitous evoked brain response elicited by any discriminable change of an otherwise regular stimulus sequence. Despite its potential clinical relevance - the MMN is known to be affected by brain state, lesions, and neurologic/psychiatric disorders - and a growing body of animal work, the underlying neurophysiology of the MMN is not well understood. This hinders translation of circuit-level animal findings and mitigates the utility of the MMN as a neurologic/psychiatric biomarker. Here, we used biophysical modeling to examine the neurophysiological basis of the MMN as measured in a canonical auditory oddball paradigm with frequency deviants (i.e., tones whose frequency was shifted slightly with respect to standard tones). The response to standards was

SUBMITTER: Fernandez Pujol C 

PROVIDER: S-EPMC12637574 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature