How long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.

ABSTRACT:

Background and aims

Inflammatory bowel disease (IBD) often coincides with pregnancy, and disease activity during pregnancy increases the risk of adverse outcomes. We aimed to determine how disease course before conception influences relapse risk during pregnancy, adjusting for established risk factors.

Methods

In this multicenter, retrospective cohort study, we included adult women with IBD who were pregnant during treatment at one of three university hospitals between 2017 and 2022. Using generalized estimating equations, we evaluated associations between relapse during pregnancy and pre-conceptional flares, categorized into three time intervals. Analyses were adjusted for phenotype, disease duration, surgical history, biologic use, smoking, and assisted reproduction. Inter

SUBMITTER: Bouwknegt DG 

PROVIDER: S-EPMC12640223 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature