Map3C: a computational tool for processing multiomic single-cell Hi-C data.

ABSTRACT: The emergence of multiomic single-cell Hi-C methods, which simultaneously profile chromatin conformation and other modalities such as gene expression or DNA methylation, creates tremendous opportunities for studying the genome's structure-function relationships. Existing tools for processing multiomic single-cell Hi-C datasets have certain limitations for downstream bioinformatics analysis. We present map3C, a software tool designed to address these limitations. We demonstrate that map3C improves the quality of multiomic single-cell Hi-C data for analysis and its utility for identifying structural variant locations in the genome.

SUBMITTER: Galasso J 

PROVIDER: S-EPMC12640563 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature