Quality by design optimization of microemulsions for topical delivery of <i>Passiflora setacea</i> seed oil.

ABSTRACT: Passiflora setacea seed oil is a natural source of bioactive unsaturated fatty acids, notably linoleic acid (ω-6) and oleic acid (ω-9), with promising antioxidant and anti-inflammatory potential for dermatological applications. However, its direct use is limited by poor physicochemical and organoleptic properties. This study aimed to develop and optimize a topical microemulsion (ME) system incorporating P. setacea seed oil using quality by design principles to address formulation challenges. The oil was extracted via Soxhlet and characterized by gas chromatography-mass spectrometry and thermal analysis. A full factorial design, followed by a Box-Behnken design, was employed to optimize the formulation based on critical quality attributes and the defined quality target product

SUBMITTER: Pereira DT 

PROVIDER: S-EPMC12642947 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature