Exploring the Correlation between Immunohistochemical Findings and Bile Constituents in Choledochal Malformation Specimens.

ABSTRACT:

Background

Inflammation and malignancy studies in choledochal cystic malformations (CDC) are scarce. This research explores the role of inflammation, bile composition, and markers like cyclooxygenase-2 (COX-2), phosphorylated ribosomal protein S6 (PS6), matrix metallopeptidase-9 (MMP9), and mammalian target of rapamycin (mTOR) in CDC.

Materials and methods

This is a cross-sectional observational study. The study was conducted between January 2021 and December 2023. Bile samples from children being operated for CDC were collected and analyzed for biochemical and enzymatic constituents, while excised specimens underwent histopathological and immunohistochemistry (IHC) COX-2, mTOR, PS6, and MMP9. Statistical analysis evaluated data relationships, including descriptive statistic

SUBMITTER: Goswami C 

PROVIDER: S-EPMC12643371 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature