Prioritizing flexible working memory representations relies on the involvement of the parahippocampal-insula network during memory reactivation.

ABSTRACT: Retrospective cues in working memory (WM) prioritize relevant information and guide attention toward target items to optimize behavior. Although the frontoparietal attention network is known to support this top-down attention mechanism, the broader cortical network behind this process remains elusive. Here, by combining EEG source localization with Bayesian non-negative matrix factorization, we identify nine WM task-related subnetworks, including two newly identified networks: the left parahippocampal-insula network (lPIN) and the right parahippocampal-insula network (rPIN). Dynamic network similarity (DNS) analysis reveals that the brain rapidly transitions into a 'silent' state following memory encoding. During retention, both retro- and neutral-cues reactivate memory representation; how

SUBMITTER: Chen C 

PROVIDER: S-EPMC12644547 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature