METTL3 promotes vascular stability in intracranial aneurysm via m6A-AMPK axis.

ABSTRACT: Intracranial aneurysm (IA) is a type of cerebrovascular complication that can result in subarachnoid hemorrhage. Published research have evidenced the involvement of METTL3, a critical mRNA m⁶A methyltransferase, in the generation of various cardiovascular diseases. However, its specific role in regulating IAs remains unclear. Our research demonstrated downregulation of METTL3 in IA patients and a significant positive correlation with AMPK expression. In vascular smooth muscle cells (VSMCs), overexpressing METTL3 led to an upregulation of contractile marker genes (SM-22α & α-SMA), while the expressions of TNF-α, IL-1β, iNOS, IL-6, MMP-9, and MMP-3 were significantly downregulated. This effect was reversed by the use of the AMPK inhibitor Compound C. Therefore, it can be postulat

SUBMITTER: Guo Z 

PROVIDER: S-EPMC12647232 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature