Proton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma.

ABSTRACT:

Importance

Proton pump inhibitors (PPI) are often prescribed to prevent steroid-induced gastritis and peptic ulcer disease in patients with glioblastoma. Yet, these drugs may enhance the activity of aldehyde dehydrogenase 1 A1 (ALDH1A1), which has been linked to protection from oxidative stress, radiotherapy, and chemotherapy.

Objective

To explore the associations of the use of potent ALDH1A1-activating PPIs (PA-PPIs) and other antacid drugs with outcomes in patients with newly diagnosed glioblastoma.

Design, setting, and participants

This meta-analysis was a secondary analysis of individual prospectively captured patient data using a dataset of 5 randomized clinical trials conducted between 2008 and 2020. Participants included patients with a new diagnosis of gliobla

SUBMITTER: Le Rhun E 

PROVIDER: S-EPMC12648345 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature