Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic review and meta-analysis.

ABSTRACT:

Background

Although low tidal volume ventilation has been shown to reduce mortality in patients with acute respiratory distress syndrome (ARDS), overall mortality remains high (30%-40%). Ultra-protective ventilation (≤4 mL/kg predicted body weight) has the potential to further decrease ventilator-induced lung injury but may result in severe hypercapnia. Extracorporeal carbon dioxide removal (ECCO₂R) could facilitate ultra-protective ventilation by alleviating carbon dioxide retention; however, supporting evidence remains limited.

Objective

To evaluate the efficacy of ECCO₂R in enabling ultra-protective ventilation strategies in patients with ARDS.

Methods

A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Librar

SUBMITTER: Zhen W 

PROVIDER: S-EPMC12648385 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature