Mitochondrial connexin 43 modulates metabolic stress adaptation in glioma cell lines.

ABSTRACT:

Background

Connexin 43 (CX43) is a hemichannel (HC)- and gap junction (GJ)-forming protein that mediates the exchange of small molecules between the intracellular and extracellular environments, as well as intercellular communication. In addition to this canonical role, recent studies have shown that its functions range from transcriptional regulation to intracellular homeostasis. The ability of CX43 to translocate into mitochondria suggests its involvement in energy metabolism. However, the functions of mitochondrial CX43 (mt-CX43) in neural cells remain unexplored.

Methods

Our study investigated the expression and localisation of mt-CX43 through western blot and immunofluorescence analyses in four immortalised human glioma cell lines: T98-G, A-172, CCF-STTG1, and U-87 MG.

SUBMITTER: Gervasi A 

PROVIDER: S-EPMC12659480 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature