Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8⁺ T cell-secreted CCL5.

ABSTRACT:

Background

Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.

Methods

A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and sarcopenia in older adults. To delineate the role of IL-33 in muscle-to-bone crosstalk, we established rat models combining weighted-bearing exercise (WBE), botulinum neurotoxin A (BoNT/A)-induced muscle atrophy, and ovariectomy (OVX), and modulated muscle IL-33 levels both non-specifically and in a muscle-specific manner. Single-cell RNA sequencing was employed to identify the mechanisms by which IL-33 influences bone metabolism, and the downstream pathway was inter

SUBMITTER: Liu M 

PROVIDER: S-EPMC12661402 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature