Low serum 1,5-anhydroglucitol is associated with increased risk of all-cause and cardiovascular mortality in type 2 diabetes: A real-world cohort study.

ABSTRACT:

Aims

Serum 1,5-anhydroglucitol (1,5-AG) indicates glycemic control over 1-2 weeks and is particularly useful for monitoring postprandial hyperglycemia. However, its predictive value for long-term outcomes in type 2 diabetes has not been fully established. Therefore, our study intends to examine the correlation between 1,5-AG and risk of all-cause and cardiovascular mortality.

Methods

In this real-world cohort study, 3721 patients with type 2 diabetes were classified by 1,5-AG levels (<6.0 and ≥6.0 μg/mL). Cox proportional hazards regression models served to analyse the link between 1,5-AG levels and risk of all-cause and cardiovascular mortality, while restricted cubic splines were employed to investigate linearity of this association.

Results

Across a median 7.4-year

SUBMITTER: Ni J 

PROVIDER: S-EPMC12673452 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature