Cardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence.

ABSTRACT:

Introduction

There is considerable potential for using Chinese Herbal Medicine to manage inflammatory co-morbidities, including cardiovascular disease, in people with HIV. However, any use would require understanding herb-drug interactions with antiretroviral (ARV) drugs to ensure safety. We evaluate evidence for the effect of selected cardioprotective Chinese herbs on the activity of cytochrome P450 (CYP) enzymes that metabolise ARV drugs.

Methods

We conducted a comprehensive review of six Chinese herbs commonly found in Chinese herbal formulas for treating cardiovascular conditions. We examined the effects of their extracts and reference bioactive molecules on CYP expression and enzymatic activity. The review focused on evidence from in vitro laboratory studies. The

SUBMITTER: Cheng WJ 

PROVIDER: S-EPMC12675451 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature